Endocrine Abstracts

Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are critical regulators of appetite, energy expenditure and glucose metabolism. POMC neurons are able to sense circulating hormones and nutrients informing about the energy status of the organism. However, the molecular mechanisms underlying nutrient-sensing in POMC neurons remain incompletely understood. Mitochondria are key organelles implicated in cellular nutrient/energy management and are...

Background and aimsNonalcoholic fatty liver disease (NAFLD) is a major health threat in both developed and developing countries and is a precursor of the more advanced liver diseases including nonalcoholic steatohepatitis (NASH), liver cirrhosis and liver cancer. One of the numerous molecules participating in the development of liver steatosis is p63. Although p63 is mainly known for its roles as a tumor suppressor and cell maintenance and renewal, we ha...